Functional Geonomics


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What is Functional Geonomics? Functional Geonomics is defined as the understanding of the function of different genes and other parts of the genome. The Human Genome Project was the first step in understanding humans at a molecular level. Many questions still remain unanswered, including the function of most of the estimated 30,000 human genes. Researchers also don't know the role of Single Nucleotide Polymorphisms (SNPs) -- just basic DNA base changes within the genome, or the role of noncoding regions and repeats in the genome.(1) In The U.K.: The European Science Foundation Programme on Integrated Approaches for Functional Genomics is supported by science and medical research councils and academies in 20 participating European countries and overseen by a steering committee consisting of a representative from each country. The programme areas are designed to bring together a wide range of functional genomics researchers, to help Europe take advantage of the new technologies and genomics information by supporting integrative approaches. (2)

Functional Geometric Projects in the U.K include:

Human Genome Project:

Human Genome Project
Human Genome Project
To access the Human Genome Project (HGP) research programme resources here at the WTSI

Copy Number Variation:


Copy Number Variation
Copy Number Variation
The CNV project examines copy number changes in the population

Cancer Genome Project:


Cancer Genome Project
Cancer Genome Project
Identifying somatically acquired sequence variants/mutations and hence genes critical in the development of human cancers

Genomic Microarrays:


Genomic Microarrays
Genomic Microarrays
Detailed analysis of genomic copy number changes in tumours

Immunogenomics:


Immunogenomics
Immunogenomics
Genetics and epigenetics of the immune subgenome and their roles in evolution and disease

Microarray Facility:


Microarray Facility
Microarray Facility
Development and use of high-density arrays for expression profiling

Molecular Cytogenetics:


Molecular Cytogenetics
Molecular Cytogenetics
Chromosome organisation and structure in human disease

Molecular Genetics & Proteomics:


Molecular Genetics & Proteomics
Molecular Genetics & Proteomics
Uses of human chromosome 22 as a model system for genomic analysis

Mouse Genomics:


Mouse Genomics
Mouse Genomics
Investigations of the function of genes using the mouse as model genetic system

Genetrap:


Genetrap
Genetrap
Sanger Institute Gene Trap Resource

Fission Yeast Functional Genomics:


Fission Yeast Functional Genomics
Fission Yeast Functional Genomics
Research focuses on genome-wide gene expression profiles and regulatory networks using DNA microarrays and molecular genetics

Atlas of Gene Expression:


Atlas of Gene Expression
Atlas of Gene Expression
Describing different cell types in adult/embryonic tissues alongside a description of expression level/localisation of protein products

Human Epigenome Project (HEP):


Human Epigenome Project (HEP)
Human Epigenome Project (HEP)
Provides an epigenetic resource of genome-wide DNA methylation reference profiles in human tissues and cell lines.

Malaria:


Malaria
Malaria
Understanding malaria from basic biology to practical applications

Pathogen Arrays:


Pathogen Arrays
Pathogen Arrays
Comparative genomics and expression profiling of small genomes

MICER:


MICER
MICER
Mutagenic Insertion and Chromosome Engineering Resource

ENCODE:


ENCODE
ENCODE
Encyclopedia Of DNA Elements project sets out to identify all functional elements in the human genome sequence

DECIPHER:


DECIPHER
DECIPHER
DatabasE of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources (3)

Resources:

(1) http://www.ornl.gov/sci/techresources/Human_Genome/faq/compgen.shtml#function

(2) http://genomicshome.com/

(3) http://www.sanger.ac.uk/PostGenomics/