Functional+Geonomics

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What is Functional Geonomics? Functional Geonomics is defined as the understanding of the function of different genes and other parts of the genome. The Human Genome Project was the first step in understanding humans at a molecular level. Many questions still remain unanswered, including the function of most of the estimated 30,000 human genes. Researchers also don't know the role of Single Nucleotide Polymorphisms (SNPs) -- just basic DNA base changes within the genome, or the role of noncoding regions and repeats in the genome.(1) In The U.K.: The European Science Foundation Programme on Integrated Approaches for Functional Genomics is supported by science and medical research councils and academies in 20 participating European countries and overseen by a steering committee consisting of a representative from each country. The programme areas are designed to bring together a wide range of functional genomics researchers, to help Europe take advantage of the new technologies and genomics information by supporting integrative approaches. (2)=====

Functional Geometric Projects in the U.K include:
= = =Human Genome Project:= To access the Human Genome Project (HGP) research programme resources here at the WTSI = = =Copy Number Variation:=

The CNV project examines copy number changes in the population = = =Cancer Genome Project:=

Identifying somatically acquired sequence variants/mutations and hence genes critical in the development of human cancers = = =Genomic Microarrays:=

Detailed analysis of genomic copy number changes in tumours = = =Immunogenomics:=

Genetics and epigenetics of the immune subgenome and their roles in evolution and disease = = =Microarray Facility:=

Development and use of high-density arrays for expression profiling = = =Molecular Cytogenetics:=

Chromosome organisation and structure in human disease = = =Molecular Genetics & Proteomics:=

Uses of human chromosome 22 as a model system for genomic analysis = = =Mouse Genomics:=

Investigations of the function of genes using the mouse as model genetic system = = =Genetrap:=

Sanger Institute Gene Trap Resource = = =Fission Yeast Functional Genomics:=

Research focuses on genome-wide gene expression profiles and regulatory networks using DNA microarrays and molecular genetics = = =Atlas of Gene Expression:=

Describing different cell types in adult/embryonic tissues alongside a description of expression level/localisation of protein products = = = = =Human Epigenome Project (HEP):=

Provides an epigenetic resource of genome-wide DNA methylation reference profiles in human tissues and cell lines. = = =Malaria:=

Understanding malaria from basic biology to practical applications = = =Pathogen Arrays:=

Comparative genomics and expression profiling of small genomes

=MICER:=

Mutagenic Insertion and Chromosome Engineering Resource = = =ENCODE:=

Encyclopedia Of DNA Elements project sets out to identify all functional elements in the human genome sequence = = =DECIPHER:=

DatabasE of Chromosomal Imbalance and Phenotype in Humans using Ensembl Resources (3)